We are all aware about the point that slimming is a mega-dollar industry. With millions, or even vast amounts of people of every age group struggling to lose weight, and also few pharmaceutically effective medications open to assist them, the desperate public will literally clutch at straws.
Each week sees the launch of the new “miracle” weight loss pill or potion and a “surefire” diet bound to help believers shed kilos like magic.
Recently dr oz and garcinia cambogia dosage became the flavour of the season. When you search the web for information on this exotic fruit extract you will be assured that the is finally the miracle just about everyone has been expecting, that can produce dramatic weight-loss. Endorsements by various TV personalities and other luminaries have added to the allure of Garcinia cambogia slimming products.
Based on a recently available local study from your Tshwane University of Technology (TUT) “this small fruit, similar to a pumpkin in appearance, is currently most popularly used and widely advertised like a weight-loss supplement”.
The comprehensive overview from TUT demonstrates that research indicates that “the extracts in addition to (-)-hydroxycitric acid (HCA), a primary organic acid component of the fruit rind, exhibited anti-obesity activity”. Additionally, it regulates the serotonin levels related to satiety, ultimately causing reduced diet.
“According to clinical trial reports, Garcinia extracts were good for obese individuals on many occasions. Furthermore, studies around the toxicity and observations during clinical studies indicate that Garcinia is safe for use. A lot of the negative reports are already associated with instances when multi ingredient formulations were consumed and also the effect could not be caused by a unique ingredient.”
The investigation does, however, caution against an increase in serotonin, especially in individuals who take medicines which are already increasing serotonin levels, such as SSRIs. Research into these effects has not been conducted.
“Moreover, regulatory authorities should provide and enforce legislation requiring the compulsory basic safety illustration showing supplements pre-marketing and develop post-marketing surveillance systems,” the investigation concluded.
Dr Ingrid van Heerden, an authorized dietitian, is of opinion that we should be cautious of garcinia, because it has not yet undergone rigorous testing. What follows is reviewed information from her pen, including her final verdict:
Often, once an individual who wants, or needs to lose excess weight, is totally hooked on the promise of a slim, sexy figure, they may be sucked in to the deception. In case the drops, wafers or powders don’t work, well then it is the fault of the user who did not comply with one or another often impossible instruction including “stick to some 500 kcal/day diet” or “drink 5 litres water a day”, never those of the diet program pill.
When eventually science and legislation meet up with the makers, they calmly take product A away from the market, change their formulation slightly, affect the name to product B, after which blithely sell product B using the same advertising gambits as before, raking within the money and pulling the wool over everyone’s eyes once again.
In keeping with the ever-changing slimming product ranges, there are actually what one could call “ingredients of the year” (sometimes an ingredient will last for only 3 to 6 months, however, many have longer life spans, and after that needless to say some are resurrected every 2-3 years).
We have now had apple cider vinegar (which contains made many a comeback over time), green leaf tea (which has earned some merit in scientific studies), hoodia (which just will not manage to make the research results that can make it a front-runner), willow bark (or salicylic acid which will work for pains and aches although not as efficacious for slimming), and classic caffeine (that has a diuretic effect thus helping you to shed weight up until you replenish this type of water inside your body, as well as a stimulant effect when taken in big amounts that may be potentially dangerous), to name but a number of.
While it is perfectly entirely possible that more extensive and well controlled scientific research will reveal an extract of Garcinia cambogia which contains a chemical called hydroxycitric acid (HCA) will assist weight-loss, we have been presently not really sure how this tamarind or brindall berry or brindleberry or Garcinia gummi-gutta works, what side-effects it might or might not have and what dosage is needed to achieve really significant fat loss.
But I hear you say: “For once we have a variety of scientific studies that had been carried out with Garcinia cambogia, so what’s the situation?”
Well a few of the studies failed to show any weight loss differences between patients who took Garcinia pills and those that took dummy pills, while other studies did show differences in weight reduction using the subjects taking pills containing Garcinia losing slightly more weight as opposed to those that did not (Marquez et al, 2012).
Some of these weight-loss differences were not quite exciting either, so that we can’t say for certain that Garcinia cambogia does promote weight-loss. In addition, it seems likely that this may not be the wonder pill it is made in the market to be.
Moreover, a lot of the studies conducted so far are already flawed (Critchley, 2013) . What it means is for example that in a single study the control and experimental subjects were not well matched (i.e. they did not have the same starting weight, age, amount of unwanted fat etc.), whilst in other studies too few subjects were utilized to the results to be significant.
To the results of studies being plausible one must compare “apples with apples” (i.e. well-matched subjects and controls) and you need more than just a handful of subjects to generate the identical result.
In the positive side, we can easily say that there exists some evidence that Garcinia cambogia products may aid fat loss during a period of 12 weeks. No reports have been conducted for prolonged periods as yet (Marquez et al, 2012), which is also considered to be a drawback.
Addititionally there is at present an argument in regards to the safety of pills containing Garcinia cambogia – one group of researchers slates the pills as dangerous and hepatotoxic (causing liver damage) (Kim et al, 2013), while another group refutes this (Clouatre & Preuss, 2013). Marquez and his awesome coworkers (2012) claim that “at the doses usually administered, no differences are already reported with regards to side effects or adverse events (those studied) in humans between individuals cured with G. cambogia and controls.”
Ano Lob (2009), a public health consultant in the United States has published a stern warning concerning the hepatotoxicity of a diet product called “Hydroxycut”, containing Garcinia cambogia. The writer collected case reports of patients who developed liver toxicity of the aforementioned fat loss product.
Evidently approximately a million units of the hydroxycitric acid product can be purchased a year in the us. The patients who developed hepatotoxicity reported signs of fatigue, nausea, vomiting, cramps, fever, chills, abdominal pain, and jaundice.
While the number of hepatotoxicity cases reported were hardly any, Lob points out that monitoring of adverse events associated with vitamin supplements like these weight reduction products is woefully inadequate in the us (as is the situation in lots of other countries, including South Africa), using the FDA only receiving about 1% of those negative reports.
Based on Lob (2009), the Poison Control Centres in the us are more inclined to receive reports of adverse events associated with dietary supplements but are not equipped to coordinate such findings.
He cites the truly sobering demonstration of something called “Metabolife 356″ that has been sold as a diet supplement in the us. Lob’s states that this manufacturers received 14 000 reports over a duration of five-years that documented “serious adverse events associated with their ephedra-containing product” which dexrpky17 heart attacks, strokes, convulsions and fatalities.
The manufacturers failed to inform the FDA or any other US government authority of those reports. As astounding since this may seem, manufacturers of health supplements usually are not required to meet any of the specifications which are strictly enforced in relation to food and pharmaceutical products (medicines), to allow them to make use of this “ethical loophole” to not publish reports of negative and harmful events.
Eventually these events stumbled on light and ephedra-containing products for slimming along with other uses were banned in the united states.
The implication contain in Lob’s warning is that HCA or Garcinia cambogia extract can be potentially toxic unless sufficient, reliable evidence on the contrary is produced available.
On the present moment, we have no idea enough about slimming items that contain garcinia cambogia side effects diarrhea to freely recommend its use. I have a tendency to accept Astell and coworkers (2013) who conducted a systematic review of double blind randomised controlled clinical trials to evaluate evidence on the efficacy of current nutritional supplements employed to control appetite and weight.
These authors figured that “According to the finding using this systematic review, the evidence will not be convincing in demonstrating that a lot of vitamin supplements used as appetite suppressants for weight loss in the treatment of obesity work well and safe.”
While we await more extensive and conclusive evidence obtained with larger amounts of well-matched test subjects treated for longer periods with the “gold standard” of double blind randomised controlled clinical trials, rather stay away from any weight-loss supplement that is not tested thoroughly.